Nanoparticles and brain tumor treatment (Record no. 75946)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05562nam a2200889 a 4500 |
| 001 - CONTROL NUMBER | |
| control field | vtls000079397 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | MTX |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m eo d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cn |||m|||a |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160715s2012 nyua foab 000 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781606504086 (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781606504222 (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 9780791860038 (print) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 0791860035 (print) |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)811139143 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (CaPaEBR)10605115 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (CaBNvSL)swl00401402 |
| 037 ## - SOURCE OF ACQUISITION | |
| Stock number | 860038 |
| Source of stock number/acquisition | ASME |
| 039 #9 - LEVEL OF BIBLIOGRAPHIC CONTROL AND CODING DETAIL [OBSOLETE] | |
| Level of rules in bibliographic description | 201607151144 |
| Level of effort used to assign nonsubject heading access points | staff |
| -- | 201605041227 |
| -- | admin |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | CaBNVSL |
| Transcribing agency | CaBNVSL |
| Modifying agency | CaBNVSL |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | R857.N34 |
| Item number | N253 2012 |
| 060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER | |
| Classification number | QT 36.5 |
| Item number | N253 2012 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610.284 |
| Edition number | 23 |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Ebook |
| 245 00 - TITLE STATEMENT | |
| Title | Nanoparticles and brain tumor treatment |
| Medium | [electronic resource] / |
| Statement of responsibility, etc. | Gerardo Caruso ... [et al.]. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | New York, N.Y. : |
| Name of publisher, distributor, etc. | ASME ; |
| Place of publication, distribution, etc. | [New York, N.Y.] (222 East 46th Street, New York, NY 10017) : |
| Name of publisher, distributor, etc. | Momentum Press, |
| Date of publication, distribution, etc. | 2012. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 electronic text (viii, 99 p.) : |
| Other physical details | ill., digital file. |
| 490 1# - SERIES STATEMENT | |
| Series statement | Biomedical and nanomedical technologies |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Includes bibliographical references (p. [81]-99). |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 1. Introduction -- |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 2. Glioma biology -- 2.1 Invasion and angiogenesis -- |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 3. Blood-brain barrier -- 3.1 Blood-brain barrier physiology -- 3.2 Blood-brain barrier transport systems -- |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 4. Nanomedicine and nanotechnology -- 4.1 Nanoparticle drug delivery -- 4.1.1 Nanoparticle distribution -- 4.1.2 Nanoparticle functionalization -- 4.1.3 Nanoparticle targeting -- 4.2 Nanomedicine and cancer -- 4.3 Nanomedicine and toxicity -- |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 5. Nanoparticle technologies -- 5.1 Polymeric and polymer-drug conjugate nanoparticles -- 5.2 Micelle nanoparticles -- 5.3 Liposomes -- 5.4 Gold and silver nanoparticles -- 5.5 Metal oxide -- 5.6 Magnetic nanoparticles -- 5.7 Carbon nanotubes -- 5.8 Fullerenes -- 5.9 Peptides nanoparticles -- 5.10 Silica nanoparticles -- 5.11 Quantum dots -- 5.12 Dendrimers -- |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 6. Nanomedicine applications in brain tumors -- 6.1 Brain tumor drug targeting -- 6.1.1 Systemic approaches -- 6.1.2 Physiological approaches -- 6.1.2.1 Receptor-mediated transcytosis -- 6.1.2.2 Adsorptive-mediated transcytosis -- 6.1.2.3 Efflux pump inhibition -- 6.1.2.4 Cell-mediated drug transport -- 6.1.3 Direct CNS approaches -- 6.1.3.1 Intracerebral routes -- 6.1.4 Drug modifications and prodrugs -- |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 7. Experimental studies -- |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 8. Conclusions -- References. |
| 506 ## - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Restricted to libraries which purchase an unrestricted PDF download via an IP. |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Despite progresses in surgery, radiotherapy, and in chemotherapy, an effective curative treatment of gliomas does not yet exist. Mortality is still close to 100% and the average survival of patients with GBM is less than 1 year. The efficacy of current anti-cancer strategies in brain tumors is limited by the lack of specific therapies against malignant cells. Besides, the delivery of the drugs to brain tumors is limited by the presence of the blood brain barrier. The oncogenesis of gliomas is characterized by several biological processes and genetic alterations, involved in the neoplastic transformation. The modulation of gene expression to more levels, such as DNA, mRNA, proteins and transduction signal pathways, may be the most effective modality to down-regulate or silence some specific gene functions. Gliomas are characterized by extensive microvascular proliferation and a higher degree of vasculature. In malignant gliomas targeted therapies efficacy is low. In this complex field, it seems to be very important to improve specific selective drugs delivery systems. Drugs, antisense oligonucleotides, small interference RNAs, engineered monoclonal antibodies and other therapeutic molecules may diffuse into CNS overcoming the BBB. Nanotechnology could be used both to improve the treatment efficacy and to reduce the adverse side effects. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Also available in print. |
| 538 ## - SYSTEM DETAILS NOTE | |
| System details note | Mode of access: World Wide Web. |
| 538 ## - SYSTEM DETAILS NOTE | |
| System details note | System requirements: Adobe Acrobat reader. |
| 588 ## - SOURCE OF DESCRIPTION NOTE | |
| Source of description note | Title from PDF t.p. (viewed on September 26, 2012). |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Nanomedicine. |
| 9 (RLIN) | 115923 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Nanoparticles. |
| 9 (RLIN) | 115924 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Brain |
| General subdivision | Tumors |
| -- | Treatment. |
| 9 (RLIN) | 115925 |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Nanomedicine. |
| 9 (RLIN) | 115923 |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Nanoparticles. |
| 9 (RLIN) | 115924 |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Brain Neoplasms |
| General subdivision | therapy. |
| 9 (RLIN) | 115926 |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nanomedicine |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nanotechnology |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nanoparticles |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nanoparticles in Brain Tumor Treatment |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nanoparticle Drug Delivery |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nanoparticle Targeting |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Blood-Brain Barrier |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Glioma |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Astrocytoma |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Glioblastoma |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Brain Tumor |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Glioma Treatment |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Brain Tumor Drug Targeting |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Angiogenesis |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Polymeric |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nanoparticles and Brain Tumors |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Carbon Nanotubes and Brain Tumors |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Fullerenes and Brain Tumors |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Silica Nanoparticles and Brain Tumors |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Micelle Nanoparticles and Brain Tumors |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Liposome and Brain Tumors |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Caruso, Gerardo. |
| 9 (RLIN) | 115927 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Print version: |
| International Standard Book Number | 0791860035 |
| -- | 9780791860038 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Biomedical and nanomedical technologies. |
| 9 (RLIN) | 115928 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://portal.igpublish.com/iglibrary/search/MPB0000052.html">http://portal.igpublish.com/iglibrary/search/MPB0000052.html</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | eBook |
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