05562nam a2200889 a 4500 vtls000079397 MTX m eo d cr cn |||m|||a 160715s2012 nyua foab 000 0 eng d 9781606504086 (electronic bk.) 9781606504222 (electronic bk.) 9780791860038 (print) 0791860035 (print) (OCoLC)811139143 (CaPaEBR)10605115 (CaBNvSL)swl00401402 860038 ASME 201607151144 staff 201605041227 admin CaBNVSL CaBNVSL CaBNVSL R857.N34 N253 2012 QT 36.5 N253 2012 610.284 23 Ebook Nanoparticles and brain tumor treatment [electronic resource] / Gerardo Caruso ... [et al.]. New York, N.Y. : ASME ; [New York, N.Y.] (222 East 46th Street, New York, NY 10017) : Momentum Press, 2012. 1 electronic text (viii, 99 p.) : ill., digital file. Biomedical and nanomedical technologies Includes bibliographical references (p. [81]-99). 1. Introduction -- 2. Glioma biology -- 2.1 Invasion and angiogenesis -- 3. Blood-brain barrier -- 3.1 Blood-brain barrier physiology -- 3.2 Blood-brain barrier transport systems -- 4. Nanomedicine and nanotechnology -- 4.1 Nanoparticle drug delivery -- 4.1.1 Nanoparticle distribution -- 4.1.2 Nanoparticle functionalization -- 4.1.3 Nanoparticle targeting -- 4.2 Nanomedicine and cancer -- 4.3 Nanomedicine and toxicity -- 5. Nanoparticle technologies -- 5.1 Polymeric and polymer-drug conjugate nanoparticles -- 5.2 Micelle nanoparticles -- 5.3 Liposomes -- 5.4 Gold and silver nanoparticles -- 5.5 Metal oxide -- 5.6 Magnetic nanoparticles -- 5.7 Carbon nanotubes -- 5.8 Fullerenes -- 5.9 Peptides nanoparticles -- 5.10 Silica nanoparticles -- 5.11 Quantum dots -- 5.12 Dendrimers -- 6. Nanomedicine applications in brain tumors -- 6.1 Brain tumor drug targeting -- 6.1.1 Systemic approaches -- 6.1.2 Physiological approaches -- 6.1.2.1 Receptor-mediated transcytosis -- 6.1.2.2 Adsorptive-mediated transcytosis -- 6.1.2.3 Efflux pump inhibition -- 6.1.2.4 Cell-mediated drug transport -- 6.1.3 Direct CNS approaches -- 6.1.3.1 Intracerebral routes -- 6.1.4 Drug modifications and prodrugs -- 7. Experimental studies -- 8. Conclusions -- References. Restricted to libraries which purchase an unrestricted PDF download via an IP. Despite progresses in surgery, radiotherapy, and in chemotherapy, an effective curative treatment of gliomas does not yet exist. Mortality is still close to 100% and the average survival of patients with GBM is less than 1 year. The efficacy of current anti-cancer strategies in brain tumors is limited by the lack of specific therapies against malignant cells. Besides, the delivery of the drugs to brain tumors is limited by the presence of the blood brain barrier. The oncogenesis of gliomas is characterized by several biological processes and genetic alterations, involved in the neoplastic transformation. The modulation of gene expression to more levels, such as DNA, mRNA, proteins and transduction signal pathways, may be the most effective modality to down-regulate or silence some specific gene functions. Gliomas are characterized by extensive microvascular proliferation and a higher degree of vasculature. In malignant gliomas targeted therapies efficacy is low. In this complex field, it seems to be very important to improve specific selective drugs delivery systems. Drugs, antisense oligonucleotides, small interference RNAs, engineered monoclonal antibodies and other therapeutic molecules may diffuse into CNS overcoming the BBB. Nanotechnology could be used both to improve the treatment efficacy and to reduce the adverse side effects. Also available in print. Mode of access: World Wide Web. System requirements: Adobe Acrobat reader. Title from PDF t.p. (viewed on September 26, 2012). Nanomedicine. 115923 Nanoparticles. 115924 Brain Tumors Treatment. 115925 Nanomedicine. 115923 Nanoparticles. 115924 Brain Neoplasms therapy. 115926 Nanomedicine Nanotechnology Nanoparticles Nanoparticles in Brain Tumor Treatment Nanoparticle Drug Delivery Nanoparticle Targeting Blood-Brain Barrier Glioma Astrocytoma Glioblastoma Brain Tumor Glioma Treatment Brain Tumor Drug Targeting Angiogenesis Polymeric Nanoparticles and Brain Tumors Carbon Nanotubes and Brain Tumors Fullerenes and Brain Tumors Silica Nanoparticles and Brain Tumors Micelle Nanoparticles and Brain Tumors Liposome and Brain Tumors Caruso, Gerardo. 115927 Print version: 0791860035 9780791860038 Biomedical and nanomedical technologies. 115928 http://portal.igpublish.com/iglibrary/search/MPB0000052.html 10 75946 75946